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  • br show any damages in these organs such as heart


    show any damages in these Ionomycin such as heart, liver, spleen, lung and kidney by hstological analysis [29,36]. However, the stratum corneum of the skin hindering transdermal drug delivery acts as a barrier. A static magnetic field from 0.5 to 2 T does not cause any known side effects and the patient compliance is high. [27,52,53] Similarly, PDT is an attractive for cancer therapies because of its remote controllability, easy applicability, and low systemic toxicity and side effects [32,57]. Meanwhile, localizing transdermal treatment allows for the avoidance of undesirable systemic effects and can prevent pessimal stimulation and toxicity.
    5. Conclusion
    In conclusion, we developed a target drug delivery system to en-hance cancer targeting under a static magnetic field and laser irradia-tion to inhibit tumor growth. The system was demonstrated to be ef-fective for the synchronization of in situ transdermal administration, a magnetic field, and laser and biological targeting. To inducing DNA damage signaling and increasing the concentration of free radicals in breast tumor cells, which are triggered by PDT with HMME and DOX chemotherapy. These results suggest that laser-activatable and mag-netic-targeting LMNs exert a synergistic effect on breast cancer inhibi-tion and it is an effective, and alternative option for superficial cancer treatment. Most importantly, the synthesized LMNs absorbed into the BC may offer a solution for challenges in cancer treatment, namely, limited penetration depth and oxygen-deficient microenvironments.
    The expenses of this work were supported by the National Natural Science Foundation of China (31370967, 31170919), China, the Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme (2014), China, the Science and Technology Planning Project of Guangdong Province (2015A020212033), China, the Science 
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