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    R. Stapleton, J. W. Lampe, F, M. Farin, & F. Z. Stanczyk. Association of CYP17, CYP19, CYP1B1, and COMT polymorphisms with serum and urinary sex hormone concentrations in postmenopausal women. Cancer Epidemiol. Prev. Biomark.
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    Ecotoxicology and Environmental Safety
    journal homepage:
    Association of wheat chaff derived silica fiber and esophageal cancer in T
    north China
    Changhong Liana, Shuzhe Xiea, Weijun Lib, Jinjiin Rand, Jian Zhangb, Zheshen Hand, Xinxin Zuoc, Linwei Tiand,∗ a Department of Surgical Oncology, Heping Hospital, Changzhi Medical College, Changzhi, China
    b School of Earth Sciences, Zhejiang University, Hangzhou, China
    c State Key Laboratory for Subtropical Mountain Ecology, College of Geographical Sciences, Fujian Normal University, Fuzhou, China
    d School of Public Health, The University of Hong Kong, 7 Sassoon Road, Hong Kong SAR, China
    Keywords: Biogenic silica fiber
    Esophageal cancer
    Taihang mountain area
    Phytolith Wheat chaff Silicified prickle 
    Background: Despite decades of research and intervention programs, the epidemic of esophageal squamous cell carcinoma (ESCC) in the Taihang Mountain area of north China has not seen convincing explanation by any risk factor yet and the incidence has not seen a substantial decrease. Based on recently disclosed association of PS-341 and wheat consumption with esophageal cancer, we revisited the hypothesis of biogenic silica in esophageal cancer development.
    Methods: From the archives of the Pathology Department of Heping Hospital, Changzhi Medical College, we selected three pairs of formalin-fixed samples, tumor tissues and distant normal tissues, of three patients op-erated for ESCC who had no history of workplace exposure to silica dust. Two pairs of dried tissue samples were used for phytolith (silica body) analysis and another pair for microanalysis with Transmission Electron Microscope (TEM).
    Results: One of the phytoliths in ESCC tumor tissue was similar to the prickle hair on the surface of wheat bract. In the mineral particles detected in the tumor tissue the predominant elements were Si, Ca, and P, whereas Si signals were not obvious in the distant normal tissue. Conclusions: The preliminary findings on the detection of phytoliths and the higher than normal Si concentration in ESCC tumor tissue warrants further testing the role of biogenic silica in esophageal cancer.
    1. Introduction
    1.1. Lingering high incidence of esophageal cancer in north China
    In the atlas of cancer mortality of 2392 counties in China, published in the 1970s, rates of esophageal cancer varied more than 10-fold and sharp contrasts were found even over short geographic distances (see Fig. S1) (Editorial Committee for the Atlas of Cancer Mortality in the People’s Republic of China, 1979; Li et al., 1981; Yang, 1980). The most studied high-incidence region of China has been the 3 North China provinces of Henan, Hebei, and Shanxi in the Taihang Mountain range, affecting a total of 90 million people. PS-341 Certain areas in this region have the highest incidence rates of esophageal cancer in the world, exceeding 100 per 100,000 population (Lin et al., 2017). Since ancestry,
    esophageal cancer has been a fearful disease in this region. This disease was so dreadful that the “Throat-God” (Hou Wang) in the “Throat-God Temple” (Houwang Miao) was once worshiped by the local residents (Yang, 1980).
    Esophageal cancer has two main histological types: esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC). ESCC is the predominant histological type in China, as well as in the “Central Asian Esophageal Cancer Belt” extending from Iran and Afghanistan to China along the Silk Road (Craddock, 1993; Jabbari et al., 2008) and the African ESCC corridor stretching south from Sudan to the Eastern Cape Province of South Africa (McCormack et al., 2017). Epidemiological studies on the causative factors of ESCC began as early as 1959 in this Taihang Mountain range of China. Despite decades of research and intervention programs, however, the epidemic of ESCC in