br In conclusion biomarkers of inflammation IL and CRP and
In conclusion, biomarkers of Concanamycin A (IL-6 and CRP) and me-tabolism (resistin) were significantly associated with increased risk of cancer mortality independent of obesity, suggesting that both pathways may play a synergistic role in creating a favorable microenvironment for tumorigenesis and prognosis. This study supports the need for im-proved risk stratification based on metabolic health and/or inflamma-tory biomarkers regardless of BMI or obesity status in predicting cancer outcomes. Interventions targeting the inflammatory and meta-bolic biomarkers may improve cancer survival.
TA led the design, analysis, interpretation of data and writing of the manuscript. DD conducted the statistical analysis and drafted the man-uscript. DD, SJ, SG, MC, MP, and MS contributed to the interpretation of data, writing and reviewing the manuscript. All authors have read and approved the final version of the manuscript.
The REGARDS study was supported by cooperative agreement U01-NS041588 from the National Institute of Neurological Disorders and Stroke, National Institutes of Health, Department of Health and Human Service. The authors thank the other investigators, the staff, and the participants of the REGARDS study for their valuable contribu-tions. A full list of participating REGARDS investigators and institutions can be found at http://www.regardsstudy.org. This analysis was sup-ported by award R01-NR012726 from the National Institute of Nursing
Research, UL1-RR025777 from the National Center for Research Re-sources, K08HL096841 and R01HL080477 from the National Heart, Lung, and Blood Institute, and by grants from the Center for Clinical and Translational Science and the Lister Hill Center for Health Policy of the University of Alabama at Birmingham. Dr. Akinyemiju was sup-ported by grant K01TW010271 from the NIH. The content is solely the responsibility of the authors and does not necessarily represent the of-ficial views of the funding agencies. Representatives of the funding agencies have been involved in the review of the manuscript but not di-rectly involved in the collection, management, analysis or interpretation of the data.
Conflict of interest
The authors declare no conflict of interest.
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